Using mice, the scientists show that repeated jet lag increases both obesity related liver disease and the risk of liver cancer. The study appears November 23 in Cancer Cell. “Liver cancer is on the rise worldwide, and in human studies we’ve now seen that patients can progress from fatty liver disease to liver cancer without any middle steps such as cirrhosis,” says David Moore, a professor of molecular and cellular biology, who led the study with Associate Professor Loning Fu, both at Baylor. “We knew we needed an animal model to examine this connection, and studies in the Fu Lab found that chronically jet-lagged mice developed liver cancer in a very similar way as that described for obese humans.” When we are exposed to light, our bodies’ central circadian clock in the brain resets. When we constantly travel through different time zones, work night shifts, or push ourselves to stay awake at the regular sleep time, our central clock is being chronically disrupted. http://footmedicaldoctor.sunshineboysquartet.com/2016/11/09/the-emerging-options-for-swift-tactics-of-deformity-in-foot/This disruption also extends to clocks in other tissues that are controlled by the central clock. By changing the times the lights went on and off during the night each week, the researchers modeled the effects of chronic jet lag in normal mice who were fed a healthy diet. They found that the mice gained weight and fat, and developed fatty liver disease, which progressed to chronic inflammation and eventually liver cancer in some cases The jetlagged mice lost normal control of liver metabolism. This included not only the buildup of fat, but also increased production of bile acids, which are produced by the liver to help us digest our food. Earlier studies have linked high bile acid levels to liver cancer, not only in mice but also in humans. The researchers found that circadian clock disruption activated two nuclear receptors that help regulate liver bile acid metabolism.
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West Texas Intermediate futures rose to $47.48 per barrel. “20,000 would be the target” on the Dow, LaRosa said. http://www.feelfreemaldives.com/alyssagriffinonline/2016/11/10/some-background-guidelines-on-uncomplicated-orthopaedic-surgery-strategies/That target is not necessarily for this year. “It just seems like money is flowing into this market. People are repositioning. People are encouraged that more investment will come into the United States. Money will come from overseas. Regulation will be lifted. Right now, the light is green,” he said. The last time the Dow, Nasdaq and S&P all closed at record highs was August 15.
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